Psychosomatic Medicine Tips for Better Browsing
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Granata, A.
Right arrow Articles by Del Rio, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Granata, A.
Right arrow Articles by Del Rio, G.

Psychosomatic Medicine, Vol 57, Issue 4 336-344, Copyright © 1995 by American Psychosomatic Society

ORIGINAL ARTICLES

Stress and the erectile response to intracavernosal prostaglandin E1 in men with erectile dysfunction

A Granata, J Bancroft and G Del Rio
Istituto di Patologia Medica-Clinica Medica 1, Universita Di Modena, Italy.

The erectile response to intracavernosal injection (ICI) of smooth muscle relaxants is often impaired in men with presumed psychogenic erectile dysfunction. This study tests the hypothesis that such impairment results from stress-related increase in circulating norepinephrine (NE). Fifty-nine men with erectile dysfunction had their nocturnal penile tumescence (NPT) monitored over 2 nights, and ICI of 10 micrograms prostaglandin E1 was given on the second morning. Psychometric and neuroendocrine measures of stress, including plasma and urinary catecholamines, were taken on both mornings. Inhibition of the ICI response was determined by the difference between NPT and ICI responses, and two groups of "high inhibition" and "low inhibition" men were compared. The high inhibition group showed higher "Trait" and "State" anxiety and a neuroendocrine profile of higher initial cortisol and lower plasma catecholamine levels than the low inhibition group. These differences were evident on both mornings and hence were not specifically related to the ICI. There was no support for the hypothesis that inhibition of response to ICI results from increased circulating NE, though the possibility that increased NE release occurred specifically in the erectile tissues could not be excluded.


This article has been cited by other articles:


Home page
 J AndrolHome page
V. Rochira, A. Balestrieri, B. Madeo, A. R. M. Granata, and C. Carani
Sildenafil Improves Sleep-Related Erections in Hypogonadal Men: Evidence From a Randomized, Placebo-Controlled, Crossover Study of a Synergic Role for Both Testosterone and Sildenafil on Penile Erections
J Androl, March 1, 2006; 27(2): 165 - 175.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
C. M. Meston and P. F. Frohlich
The Neurobiology of Sexual Function
Arch Gen Psychiatry, November 1, 2000; 57(11): 1012 - 1030.
[Abstract] [Full Text] [PDF]

Home page
 Psychosom. Med.Home page
J. Bancroft
Cardiovascular and Endocrine Changes During Sexual Arousal and Orgasm
Psychosom Med, May 1, 1999; 61(3): 290 - 291.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Psychosomatic Society