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Psychosomatic Medicine, Vol 58, Issue 6 524-545, Copyright © 1996 by American Psychosomatic Society

ORIGINAL ARTICLES

Use of animal models in peptic ulcer disease

H Weiner
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, School of Medicine 90095, USA.

Considerable progress has been made in the understanding of the formation of gastric erosions by the use of animals. The role of gastric acid secretion in their pathogenesis has been clarified. Gastric erosions are associated with the presence of acid in the stomach and slow gastric contractions. With several different experimental procedures, the animal's body temperature falls; preventing the fall averts erosions. A fall in body temperature or exposure to cold are associated with the secretion of thyrotropin-releasing hormone (TRH), and both increased and decreased concentration of corticotropin-releasing factor (CRH) in discrete regions of rat brains. Thyrotropin-releasing hormone when injected into specific sites in the brain produces gastric erosions and increases acid secretion and slow contractions, whereas CRH has the opposite effects. One of the major sites of interaction of the two peptides is in the dorsal motor complex of the vagus nerve. Thyrotropin-releasing hormone increases serotonin (5-HT) secretion into the stomach. Serotonin counter-regulates acid secretion and slow contractions. Many other peptides injected into discrete brain sites stimulate or inhibit gastric acid secretion.


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K. Miyata, H. Ito, and S. Fukudo
Involvement of the 5-HT3 receptor in CRH-induced defecation in rats
Am J Physiol Gastrointest Liver Physiol, May 1, 1998; 274(5): G827 - G831.
[Abstract] [Full Text] [PDF]


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Copyright © 1996 by the American Psychosomatic Society