This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Domino, E. F. Search for Related Content PubMed PubMed Citation Articles by Domino, E. F. Related Collections History and Humanities Pharmacology

History of Modern Psychopharmacology: A Personal View With an Emphasis on Antidepressants

From the Professor, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan.

Address reprint requests to: E. F. Domino, MD, Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632.

OBJECTIVE: This article provides the chemical basis for the molecular modification of H₁ antihistamines in the rational development of some antidepressant and antipsychotic drugs.

METHODS: A review of the literature and personal experiences have been compiled.

CONCLUSIONS: The contributions of many basic scientists, the crucial observations of clinicians, and the desire of the drug industry to make money have resulted in the currently available psychopharmacological treatments. The future development of psychopharmacology depends on better clinical research to generate new hypotheses of the chemical and behavioral pathology of mental disease. Psychosomatic medicine can make a unique contribution in its interdisciplinary role of stressing brain, body, and mind relationships.

Key Words: history • psychopharmacology • antidepressants

Abbreviations: DMT = dimethyltryptamine; 5-MEODMT =5-methoxydimethyltryptamine; MAO = monoamine oxidase; SAR =structure activity relationship; SSRI = selective serotoninreuptake inhibitors.

This article has been cited by other articles:

				O. G. Cameron Psychopharmacology Psychosom Med, September 1, 1999; 61(5): 585 - 590. [Full Text] [PDF]