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History of Modern Psychopharmacology: A Personal View With an Emphasis on Antidepressants

From the Professor, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan.

Address reprint requests to: E. F. Domino, MD, Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632.

OBJECTIVE: This article provides the chemical basis for the molecular modification of H₁ antihistamines in the rational development of some antidepressant and antipsychotic drugs.

METHODS: A review of the literature and personal experiences have been compiled.

CONCLUSIONS: The contributions of many basic scientists, the crucial observations of clinicians, and the desire of the drug industry to make money have resulted in the currently available psychopharmacological treatments. The future development of psychopharmacology depends on better clinical research to generate new hypotheses of the chemical and behavioral pathology of mental disease. Psychosomatic medicine can make a unique contribution in its interdisciplinary role of stressing brain, body, and mind relationships.

Key Words: history • psychopharmacology • antidepressants

Abbreviations: DMT = dimethyltryptamine; 5-MEODMT =5-methoxydimethyltryptamine; MAO = monoamine oxidase; SAR =structure activity relationship; SSRI = selective serotoninreuptake inhibitors.

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