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Effect of Risperidone on Prolactinoma Growth in a Psychotic Woman

From the Department of Psychiatry, Mt. Sinai Hospital, Chicago and Finch University of Health Sciences/The Chicago Medical School, North Chicago, IL.

Address reprint requests to: Jayanta K. Pal, MD, 4825 Kirk St., Apt. 2N, Skokie, IL 60077.

OBJECTIVE: The case of a psychotic woman is described in which risperidone use was found to correspond with an increase in the size of a prolactinoma and prevented the return of serum prolactin level to baseline.

METHODS: Although the patient had been treated with a high dose of bromocriptine, her prolactin level remained elevated, causing persistent galactorrhea. The patient later was treated with olanzapine and carbamazepine successfully.

RESULTS: This case report highlights the role of risperidone on prolactin and discusses alternative methods of treating psychosis when the etiology is unclear, especially in younger patients.

CONCLUSIONS: The authors recommend that additional studies regarding the relationship between the growth of prolactinoma and atypical antipsychotics would be worthwhile.

Key Words: psychosis • prolactinoma • atypical antipsychotic.

Abbreviations: D2 = dopaminergic; EEG = electroencephalogram; MRI = magnetic resonance imaging; GABA = gamma-aminobutyric acid.

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