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Are Women With Premenstrual Dysphoric Disorder Prone to Osteoporosis?

From the BioBehavioral Program, School of Medicine and Biomedical Sciences, State University of New York at Buffalo.

Address reprint requests to: Uriel Halbreich, MD, BioBehavioral Program, School of Medicine and Biomedical Sciences, SUNY Clinical Center, Room BB170, 462 Grider St., Buffalo, NY 14215. Email: urielh{at}acsu.buffalo.edu

OBJECTIVE: The objective of this study was to examine whether bone mineral density (BMD) is reduced in women with premenstrual dysphoric disorder (PMDD).

METHODS: Thirty-eight healthy women participated: 20 with prospectively confirmed PMDD and 18 without PMDD. Bone mass was measured using dual-energy x-ray absorptiometry at three sites: lumbar spine anteroposterior, lumber spine lateral, and femoral neck. Results from the PMDD and control groups were compared with each other and with age- and sex-matched normative data.

RESULTS: The BMD of both groups was as expected for their age and sex, and groups did not differ in BMD or Z scores for any of the bone sites studied.

CONCLUSIONS: If women with PMDD are at an increased risk of developing osteoporosis, this risk is not manifested in their BMD.

Key Words: premenstrual dysphoric disorder • premenstrual syndrome • osteoporosis • bone metabolism.

Abbreviations: AP = anteroposterior; BMD = bone mineral density; DSM-III-R =Diagnostic and Statistical Manual of Mental Disorders, third edition, revised; DSM-IV =Diagnostic and Statistical Manual of Mental Disorders, fourth edition; DXA = dual-energy x-ray absorptiometry; LLPDD = late luteal phase dysphoric disorder; PMDD = premenstrual dysphoric disorder; PMS = premenstrual syndrome; SCID = Structured Clinical Interview for DSM-III-R.

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