This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wilhelm, F. H. Articles by Roth, W. T. Search for Related Content PubMed PubMed Citation Articles by Wilhelm, F. H. Articles by Roth, W. T. Related Collections Anxiety Pulmonary

Slow Recovery From Voluntary Hyperventilation in Panic Disorder

From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford and the Department of Veterans Affairs Health Care System, Palo Alto, California. Dr. Gerlach is currently at the Westfälische Wilhelms-Universität Münster, Germany.

Address reprint requests to: Frank Wilhelm, Stanford University/VAPAHCS (116F-PAD), 3801 Miranda Ave., Palo Alto, CA 94304. Email: fwilhelm{at}stanford.edu

OBJECTIVE: Because hyperventilation has figured prominently in theories of panic disorder (PD) but not of social phobia (SP), we compared predictions regarding diagnosis-specific differences in psychological and physiological measures before, during, and after voluntary hyperventilation.

METHOD: Physiological responses were recorded in 14 patients with PD, 24 patients with SP, and 24 controls during six cycles of 1-minute of fast breathing alternating with 1 minute of recovery, followed by 3 minutes of fast breathing and 10 minutes of recovery. Speed of fast breathing was paced by a tone modulated at 18 cycles/minute, and depth by feedback aimed at achieving an end-tidal pCO₂ of 20 mm Hg. These values were reached equally by all groups.

RESULTS: During fast breathing, PD and SP patients reported more anxiety than controls, and their feelings of dyspnea and suffocation increased more from baseline. Skin conductance declined more slowly in PD over the six 1-minute fast breathing periods. At the end of the final 10-minute recovery, PD patients reported more awareness of breathing, dyspnea, and fear of being short of breath, and their pCO₂s, heart rates, and skin conductance levels had returned less toward normal levels than in other groups. Their lower pCO₂s were associated with a higher frequency of sigh breaths.

CONCLUSIONS: PD and SP patients report more distress than controls to equal amounts of hypocapnia, but PD differ from SP patients and controls in having slower symptomatic and physiological recovery. This finding was not specifically predicted by hyperventilation, cognitive-behavioral, or suffocation alarm theories of PD.

Key Words: Panic disorder • social phobia • hypocapnia • respiration • respiratory sinus arrhythmia • autonomic nervous system

Abbreviations: HV = hyperventilation; PD = panic disorder; SP = social phobia; CO₂ = carbon dioxide; pCO₂ = partial pressure of CO₂; RSA = respiratory sinus arrhythmia; SC = skin conductance; STAI = Spielberger State-Trait Anxiety Inventory; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, 4th Edition; FB = fast breathing; ANOVA = analysis of variance; ANCOVA = analysis of covariance; SD = standard deviation

This article has been cited by other articles:

				J. Blechert, T. Michael, P. Grossman, M. Lajtman, and F. H. Wilhelm Autonomic and Respiratory Characteristics of Posttraumatic Stress Disorder and Panic Disorder Psychosom Med, November 1, 2007; 69(9): 935 - 943. [Abstract] [Full Text] [PDF]

				T. Ritz and B. Dahme Implementation and Interpretation of Respiratory Sinus Arrhythmia Measures in Psychosomatic Medicine: Practice Against Better Evidence? Psychosom Med, July 1, 2006; 68(4): 617 - 627. [Abstract] [Full Text] [PDF]

				S. D. Friedman, C. M. Mathis, C. Hayes, P. Renshaw, and S. R. Dager Brain pH Response to Hyperventilation in Panic Disorder: Preliminary Evidence for Altered Acid-Base Regulation Am J Psychiatry, April 1, 2006; 163(4): 710 - 715. [Abstract] [Full Text] [PDF]

				T. Ritz, F. H. Wilhelm, A. L. Gerlach, A. Kullowatz, and W. T. Roth End-Tidal pCO2 in Blood Phobics During Viewing of Emotion- and Disease-Related Films Psychosom Med, July 1, 2005; 67(4): 661 - 668. [Abstract] [Full Text] [PDF]

				P M Meek Measurement of dyspnea in chronic obstructive pulmonary disease: what is the tool telling you? Chronic Respiratory Disease, January 1, 2004; 1(1): 29 - 37. [Abstract] [PDF]

				F. H. Wilhelm, W. T. Roth, and M. A. Sackner The LifeShirt: An Advanced System for Ambulatory Measurement of Respiratory and Cardiac Function Behav Modif, October 1, 2003; 27(5): 671 - 691. [Abstract] [PDF]