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From the Departments of Psychiatry and Behavioral Sciences (H.S.L., J.A.B., M.A.B., A.S., C.R.) and Anesthesiology (M.F.N.), Duke University Medical Center, Durham, North Carolina; and the Department of Psychology: Social and Health Sciences (T.S.), Duke University, Durham, North Carolina.
Address correspondence and reprint requests to: Heather Lett, MA, Box 3119, Duke University Medical Center, Durham, NC 27710. E-mail: lett0002{at}mc.duke.edu
OBJECTIVE: The present paper reviews the evidence that depression is a risk factor for the development and progression of coronary artery disease (CAD).
METHODS: MEDLINE searches and reviews of bibliographies were used to identify relevant articles. Articles were clustered by theme: depression as a risk factor, biobehavioral mechanisms, and treatment outcome studies.
RESULTS: Depression confers a relative risk between 1.5 and 2.0 for the onset of CAD in healthy individuals, whereas depression in patients with existing CAD confers a relative risk between 1.5 and 2.5 for cardiac morbidity and mortality. A number of plausible biobehavioral mechanisms linking depression and CAD have been identified, including treatment adherence, lifestyle factors, traditional risk factors, alterations in autonomic nervous system (ANS) and hypothalamic pituitary adrenal (HPA) axis functioning, platelet activation, and inflammation.
CONCLUSION: There is substantial evidence for a relationship between depression and adverse clinical outcomes. However, despite the availability of effective therapies for depression, there is a paucity of data to support the efficacy of these interventions to improve clinical outcomes for depressed CAD patients. Randomized clinical trials are needed to further evaluate the value of treating depression in CAD patients to improve survival and reduce morbidity.
Key Words: depression, • coronary artery disease, • physiological mechanisms, • behavioral mechanisms, • randomized clinical trials.
Abbreviations: AMI = acute myocardial infarction;; ANS = autonomic nervous system;; BDI = Beck Depression Inventory;; CABG = coronary artery bypass graft;; CAD = coronary artery disease;; CBT = cognitive behavior therapy;; CES-D = Center for Epidemiological Studies Depression Questionnaire;; CHD = coronary heart disease;; CHF = congestive heart failure;; DIS = Diagnostic Interview Schedule;; ENRICHD = Enhancing Recovery in Coronary Heart Disease;; HBP = high blood pressure;; HPA = hypothalamic pituitary adrenal;; HRV = heart rate variability;; IHD = ischemic heart disease;; MDD = major depressive disorder;; SNS = sympathetic nervous system;; SSRI = selective serotonin reuptake inhibitor.
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