| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
ORIGINAL ARTICLES |
From the Stanford Center for Research in Disease Prevention (L.S.K., M.R.C., L.P.P., A.C.K., S.P.F.), Stanford University School of Medicine, Stanford, CA. M.R.C. is now at the Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Address correspondence and reprint requests to Dr. Leslie S. Kinder, VA Puget Health Care System, 1660 S. Columbian Way, Seattle, WA 98108. E-mail: lskinder{at}stanfordalumni.org
OBJECTIVE: Previous reports have suggested that depression may lead to the development of cardiovascular disease through its association with the metabolic syndrome; however, little is known about the relationship between depression and the metabolic syndrome. The aim of this study was to establish an association between depression and the metabolic syndrome in a nationally representative sample.
METHODS: The Third National Health and Nutrition Examination Survey is a population-based health survey of noninstitutionalized US citizens completed between 1988 and 1994. Three thousand one hundred eighty-six men and 3003 women, age 17 to 39, free of coronary heart disease and diabetes, completed the depression module from the Diagnostic Interview Schedule and a medical examination that provided clinical data needed to establish the presence of the metabolic syndrome, as defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol in Adults.
RESULTS: Women with a history of a major depressive episode were twice as likely to have the metabolic syndrome compared with those with no history of depression. The relationship between depression and metabolic syndrome remained after controlling for age, race, education, smoking, physical inactivity, carbohydrate consumption, and alcohol use. Men with a history of depression were not significantly more likely to have the metabolic syndrome.
CONCLUSIONS: The prevalence of the metabolic syndrome is elevated among women with a history of depression. It is important to better understand the role depression may play in the effort to reduce the prevalence of the metabolic syndrome and its health consequences.
Key Words: depression, the metabolic syndrome, the Third National Health and Nutrition Examination Survey.
Abbreviations: ATP III = Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol in Adults (Adult Treatment Panel III);; CHD = coronary heart disease;; CI = confidence interval;; CVD = cardiovascular disease;; DSM III-R = Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised;; HPA = hypothalamic-pituitary-adrenal;; MDE = major depressive episode;; NHANES III = The Third National Health and Nutrition Examination Survey;; OR = odds ratio.
This article has been cited by other articles:
![]() |
M. J. Weigensberg, C. M. Toledo-Corral, and M. I. Goran Association between the Metabolic Syndrome and Serum Cortisol in Overweight Latino Youth J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1372 - 1378. [Abstract] [Full Text] [PDF] |
||||
![]() |
U. Schweiger, W. Greggersen, S. Rudolf, M. Pusch, T. Menzel, S. Winn, J. Hassfurth, E. Fassbinder, K. G. Kahl, K. M. Oltmanns, et al. Disturbed Glucose Disposal in Patients With Major Depression; Application of the Glucose Clamp Technique Psychosom Med, February 1, 2008; 70(2): 170 - 176. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Vaccarino, C. McClure, B. D. Johnson, D. S. Sheps, V. Bittner, T. Rutledge, L. J. Shaw, G. Sopko, M. B. Olson, D. S. Krantz, et al. Depression, the Metabolic Syndrome and Cardiovascular Risk Psychosom Med, January 1, 2008; 70(1): 40 - 48. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Sachs-Ericsson, A. B. Burns, K. H. Gordon, L. A. Eckel, S. A. Wonderlich, R. D. Crosby, and D. G. Blazer Body Mass Index and Depressive Symptoms in Older Adults: The Moderating Roles of Race, Sex, and Socioeconomic Status Am J Geriatr Psychiatry, September 1, 2007; 15(9): 815 - 825. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Vogelzangs, A. T. F. Beekman, S. B. Kritchevsky, A. B. Newman, M. Pahor, K. Yaffe, S. M. Rubin, T. B. Harris, S. Satterfield, E. M. Simonsick, et al. Psychosocial Risk Factors and the Metabolic Syndrome in Elderly Persons: Findings From the Health, Aging and Body Composition Study J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2007; 62(5): 563 - 569. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. A. Bermudes, P. E. Keck Jr., and J. A. Welge The Prevalence of the Metabolic Syndrome in Psychiatric Inpatients With Primary Psychotic and Mood Disorders Psychosomatics, December 1, 2006; 47(6): 491 - 497. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Mallik, J. A. Spertus, K. J. Reid, H. M. Krumholz, J. S. Rumsfeld, W. S. Weintraub, P. Agarwal, M. Santra, S. Bidyasar, J. H. Lichtman, et al. Depressive Symptoms After Acute Myocardial Infarction: Evidence for Highest Rates in Younger Women. Arch Intern Med, April 24, 2006; 166(8): 876 - 883. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Nabkasorn, N. Miyai, A. Sootmongkol, S. Junprasert, H. Yamamoto, M. Arita, and K. Miyashita Effects of physical exercise on depression, neuroendocrine stress hormones and physiological fitness in adolescent females with depressive symptoms Eur J Public Health, April 1, 2006; 16(2): 179 - 184. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Herva, P. Rasanen, J. Miettunen, M. Timonen, K. Laksy, J. Veijola, J. Laitinen, A. Ruokonen, and M. Joukamaa Co-occurrence of metabolic syndrome with depression and anxiety in young adults: the Northern Finland 1966 Birth Cohort Study. Psychosom Med, March 1, 2006; 68(2): 213 - 216. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. J. Shaw, C. N. Bairey Merz, C. J. Pepine, S. E. Reis, V. Bittner, S. F. Kelsey, M. Olson, B. D. Johnson, S. Mankad, B. L. Sharaf, et al. Insights From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part I: Gender Differences in Traditional and Novel Risk Factors, Symptom Evaluation, and Gender-Optimized Diagnostic Strategies J. Am. Coll. Cardiol., February 7, 2006; 47(3_Suppl_S): S4 - S20. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. J. Lehman, S. E. Taylor, C. I. Kiefe, and T. E. Seeman Relation of Childhood Socioeconomic Status and Family Environment to Adult Metabolic Functioning in the CARDIA Study Psychosom Med, November 1, 2005; 67(6): 846 - 854. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. M. Reaven The Metabolic Syndrome: Requiescat in Pace Clin. Chem., June 1, 2005; 51(6): 931 - 938. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |