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Psychosomatic Medicine 66:533-537 (2004)
© 2004 American Psychosomatic Society

ORIGINAL ARTICLES

Depression and Bone Mineral Density in Young Adults: Results From NHANES III

Michael E. Mussolino, MA, Bruce S. Jonas, ScM, PhD and Anne C. Looker, PhD

From the Centers for Disease Control and Prevention, National Center for Health Statistics.

Address correspondence to Michael E. Mussolino, Centers for Disease Control and Prevention, National Center for Health Statistics, 3311 Toledo Road, Room 6431, Hyattsville, MD 20782. E-mail: MMussolino{at}cdc.gov

OBJECTIVE: The purpose of this cross-sectional population-based study was to assess the association of major depressive episode (MDE) and dysthymia with bone mineral density (BMD) in young adults.

METHODS: Data are from a nationally representative sample of 5,171 people aged 20 to 39 years from the Third National Health and Nutrition Examination Survey. Total proximal femoral BMD was measured using dual energy x-ray absorptiometry. MDE and dysthymia were measured using the Diagnostic Interview Schedule.

RESULTS: MDE was associated with lower BMD in multivariate models in men (mean BMD = 1.038 vs. 1.068 g/cm2; odds ratio (OR) per 1 SD decline in BMD = 1.65, 95% confidence interval (CI) = 1.08–2.52; p = 0.02) but not in women (mean BMD = 0.982 vs. 0.979 g/cm2; OR = 0.96, 95% CI = 0.71–1.30; p = .79). The same divergence by gender was seen for dysthymia.

CONCLUSION: The relationship between BMD and MDE or dysthymia in young adults varies by gender.

Key Words: bone mineral density; depression, • dysthymia, • representative sample, • young adults.

Abbreviations: MDE = major depressive episode;; BMD = bone mineral density;; NHANES III = Third National Health and Nutrition Examination Survey;; DIS = Diagnostic Interview Schedule.




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