This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Herbst, S. Articles by Petry, N. M. Search for Related Content PubMed PubMed Citation Articles by Herbst, S. Articles by Petry, N. M. Related Collections Aging Anxiety Depression Overweight or Obesity Coronary Artery Disease

Lifetime Major Depression is Associated With Coronary Heart Disease in Older Adults: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

From the Department of Psychiatry (S.H., R.H.P., N.M.P.), University of Connecticut School of Medicine; Department of Oral Health and Diagnostic Sciences (J.W.), University of Connecticut School of Dental Medicine; and Pat and Jim Calhoun Cardiology Center (W.B.W.), Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.

Address correspondence and reprint requests to Nancy M. Petry, Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3944. E-mail: petry{at}psychiatry.uchc.edu

Objective: To examine the association between mood and anxiety disorders and coronary heart disease (CHD) in a nationally representative sample of older adults.

Methods: Data from the National Epidemiologic Survey on Alcohol and Related Conditions were analyzed with 10,573 adults aged 60 years surveyed.

Results: A total of 13.30% of older adults reported diagnoses of CHD. Age (odds ratio (OR) = 1.04), morbid obesity (OR = 1.60), hypertension (OR = 2.29), lifetime nicotine dependence (OR = 1.41), and lifetime drug use disorders (OR = 2.19) were all significantly related to CHD. Being female (OR = 0.73) relative to male and a lifetime social drinker (OR = 0.71) compared with alcohol abstainers decreased the odds of CHD. After controlling for these characteristics, the presence of a lifetime major depressive episode was significantly associated with increased risk of CHD (OR = 2.05), but the lifetime anxiety disorders assessed were not. The association between lifetime mood disorders and CHD was similar for both genders, and single versus multiple depressive episodes conferred equal risk of CHD.

Conclusions: These data demonstrate that a lifetime major depressive episode increases the risk of CHD in older adults.

Key Words: coronary heart disease • mood disorders • anxiety disorders • older adults

Abbreviations: CHD = coronary heart disease; NIAAA = National Institute on Alcohol Abuse and Alcoholism; NESARC = National Epidemiologic Survey on Alcohol and Related Conditions; AUDADIS = Alcohol Use Disorder and Associated Disabilities Interview Schedule; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders—Fourth Edition; BMI = body mass index; OR = odds ratio; CI = confidence interval.

This article has been cited by other articles:

				T. Rutledge, S. E. Linke, D. S. Krantz, B. D. Johnson, V. Bittner, J.-A. Eastwood, W. Eteiba, C. J. Pepine, V. Vaccarino, J. Francis, et al. Comorbid Depression and Anxiety Symptoms as Predictors of Cardiovascular Events: Results From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study Psychosom Med, November 1, 2009; 71(9): 958 - 964. [Abstract] [Full Text] [PDF]

				H. M. Gonzalez, T. Croghan, B. West, D. Williams, R. Nesse, W. Tarraf, R. Taylor, L. Hinton, H. Neighbors, and J. Jackson Antidepressant Use in Black and White Populations in the United States Psychiatr Serv, October 1, 2008; 59(10): 1131 - 1138. [Abstract] [Full Text] [PDF]