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Vulnerable Caregivers of Patients With Alzheimer’s Disease Have a Deficit in Circulating CD62L^- T Lymphocytes

From the Departments of Psychiatry (P.M., H.Y., T.P., I.G.) and Medicine (M.Z.), University of California, San Diego, and Veterans Administration Medical Center (T.P., I.G.), La Jolla, California.

View larger version (52K): [in a new window]   Fig. 1. In both groups, acute psychological stress led to a significant increase over rest in circulating levels of CD8+CD62L- (top) and CD8+CD62L+ (bottom) T cells (p<.001). Compared with nonvulnerable caregivers, vulnerable caregivers had lower levels of CD8+CD62L- cells at rest and following the task (p=.01) but no difference in CD8+CD62L+ cells (mean,±SEM).

View larger version (54K): [in a new window]   Fig. 2. Neither CD4+CD62L- (top) or CD4+CD62L+ (bottom) T cells increased significantly over baseline following the acute stressor. Vulnerable caregivers, however, had significantly lower levels of CD4+CD62L- T cells at both time points (p=.01) but not CD4+CD62L+ T cells (mean,±SEM).