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Treatment of Depression With Antiglucocorticoid Drugs

Owen M. Wolkowitz, MD and Victor I. Reus, MD

From the Department of Psychiatry (O.M.W., V.I.R.), University of California, San Francisco, School of Medicine, San Francisco, CA.



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  		Fig. 1. Steroid metabolic pathway. DHEA = dehydroepiandrosterone; DHEA-S = dehydroepiandrosterone sulfate; HSD = hydroxysteroid dehydrogenase; SCC = side-chain cleavage; SST = steroid sulfotransferase; 1 = site of blockade by ketoconazole; 2 = site of blockade by metyrapone; 3 = site of blockade by aminoglutethimide.

 




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