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Salivary MUC5B-Mediated Adherence (Ex Vivo) of Helicobacter pylori During Acute Stress

Jos A. Bosch, MSc, Eco J. C. de Geus, PhD, Toon J. M. Ligtenberg, PhD, Kamran Nazmi, BSc, Enno C. I. Veerman, PhD, Johan Hoogstraten, PhD and Arie V. Nieuw Amerongen, PhD

From the Departments of Oral Biology (J.A.B., T.J.M.L, K.N., E.C.I.V., A.V.N.A.), Community Dentistry and Dental Health Education (J.H.), Academic Centre for Dentistry Amsterdam; and Faculty of Psychology (E.J.C.D.G.), Department of Biological Psychology, Vrije Universiteit (E.J.C.D.G), Amsterdam, The Netherlands.



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  		Fig. 1. Values of sulfo-Lea concentration (U/ml), sulfo-Lea output (U/min), and sulfo-Lea/total protein ratio (U/mg protein). Values are expressed in ELISA units (U). Bars and error bars indicate mean values and standard errors, respectively. Horizontal lines indicate median values. For statistical analysis, log-transformed values were used.

 


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  		Fig. 2. Saliva-mediated adherence (ex vivo) of H. pylori. Bars and error bars indicate mean values and standard errors, respectively. Horizontal lines indicate median values. Adherence is quantified as an index value based on a pooled saliva sample as a standard, indexed on 100.

 


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  		Fig. 3. Effects of preincubation of H. pylori suspension with 0, 100, 400, and 1600 µg/ml MUC5B. These results show that preincubation of H. pylori reduces adherence in a dose-dependent manner, indicating that the observed adherence is MUC5B dependent. Adherence was quantified as an index value based on a pooled saliva sample as a standard.

 




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