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Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans

From the Department of Psychiatry (O.G.C., J.K.Z.) and Department of Internal Medicine, Section of Nuclear Medicine and PET Center (J.K.Z., S.M.), University of Michigan Medical Center, Ann Arbor, MI; and Department of Psychiatry (L.G.), Sackler Medical School, Tel Aviv, Israel.

View larger version (32K): [in a new window]   Fig. 1. Z-score significance map of absolute decreases in regional CBF in response to intravenous yohimbine (placebo scan minus yohimbine scan). Scan slices are horizontal at millimeter (mm) levels above (+) or below (-) the AC-PC line as indicated. Difference in each voxel is represented by color coding. Color coding bar indicating correspondence of color to Z-score appears on the Figure (maximum Z-score = 3.50). Right and left are reversed. Map is overlaid on a generic magnetic resonance imaging (MRI) template to provide anatomical orientation.

View larger version (32K): [in a new window]   Fig. 2. Z-score significance map of normalized increases in regional CBF in response to intravenous yohimbine (yohimbine scan minus placebo scan). Normalization was performed by dividing each voxel value by whole brain value. Scan slices are horizontal at millimeter (mm) levels above (+) or below (-) the AC-PC line as indicated. Difference in each voxel is represented by color coding. Color coding bar indicating correspondence of color to Z-score appears on the Figure (maximum Z-score = 5.50). Right and left are reversed. Map is overlaid on a generic MRI template to provide anatomical orientation.