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Epstein-Barr Virus Antibodies in Whole Blood Spots: A Minimally Invasive Method for Assessing an Aspect of Cell-Mediated Immunity

From the Department of Anthropology (T.W.McD.), Northwestern University, Evanston, IL; Department of Anthropology (J.F.S., C.M.W.), Emory University, Atlanta, GA; Center for Developmental Epidemiology (A.A., E.J.C.), Duke University Medical Center, Durham, NC; Department of Social and Behavioral Sciences (M.B.), Arizona State University West, Phoenix, AZ; Department of Psychology (J.T.C.), University of Chicago, Chicago, IL; and Department of Molecular Virology, Immunology and Medical Genetics (R.G.), Ohio State University Medical Center, Columbus, OH.

View larger version (22K): [in a new window]   Fig. 1. Correlation between plasma and blood spot EBV p18-VCA antibody titer.

View larger version (23K): [in a new window]   Fig. 2. Correlation between blood spot ELISA method and plasma IF.

View larger version (22K): [in a new window]   Fig. 3. Stability of EBV p18-VCA antibodies in whole blood spots over 8 weeks at 37°C, room temperature, and 4°C.

View larger version (15K): [in a new window]   Fig. 4. Relationship between traumatic life events and EBV p18-VCA antibody titer under conditions of low and high life strain. Pearson R indicates the strength of the relationship between number of life events and log p18-VCA antibody titer, controlling for age.