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Interleukin-6 and Tumor Necrosis Factor- Production After Acute Psychological Stress, Exercise, and Infused Isoproterenol: Differential Effects and Pathways

From the Departments of Psychiatry (M.U.G., P.J.M., M.R.I.) and Medicine (M.G.Z.), University of California, San Diego, La Jolla, CA; Department of Medical Psychology (M.U.G.), University of Essen, Essen, Germany; and Veterans Affairs Medical Center (M.R.I.), La Jolla, CA.

View larger version (31K): [in a new window]   Fig. 1. Levels of LPS-induced TNF- and IL-6 production after public speaking and bicycle ergometer exercise tasks. IL-6 increased significantly after the speech and exercise tasks (***p values < .001). TNF- production did not change significantly after the speech task but was moderately elevated after the exercise task (*p < .05).

View larger version (58K): [in a new window]   Fig. 2. Levels of LPS-induced TNF- and IL-6 production after isoproterenol infusion. Isoproterenol decreased TNF- production (**p < .01), but IL-6 production was unaffected.