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Reductions in Herpes Simplex Virus Type 2 Antibody Titers After Cognitive Behavioral Stress Management and Relationships With Neuroendocrine Function, Relaxation Skills, and Social Support in HIV-Positive Men

Stacy Cruess, PhD, Michael Antoni, PhD, Dean Cruess, PhD, Mary Ann Fletcher, PhD, Gail Ironson, MD, PhD, Mahendra Kumar, PhD, Susan Lutgendorf, PhD, Adele Hayes, PhD, Nancy Klimas, MD and Neil Schneiderman, PhD

From the Departments of Psychology (S.C., M.A., D.C., G.I., M.K., A.H., N.S.), Psychiatry and Behavioral Sciences (M.A., G.I., M.K., N.S.), Medicine (M.A.F., N.K., N.S.), and Biomedical Engineering (N.S.), University of Miami, Miami, FL; and the Department of Psychology (S.L.), University of Iowa, Iowa City, IA.



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  		Fig. 1. Bivariate distribution of pre- and posttreatment HSV-2 IgG antibody titer levels and cortisol/DHEA-S ratio ({Delta}) change scores.

 


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  		Fig. 2. Bivariate distribution of pre- and posttreatment HSV-2 IgG antibody titer levels and SPS guidance ({Delta}) change scores.

 


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  		Fig. 3. Mediation analysis showing the relationship between group assignment and change in HSV-2 IgG antibody titers once changes in SPS guidance are controlled for. HSV-2 IgG values were first regressed on change in total IgG levels. Numbers inside parentheses represent standardized ß weights in the regression analysis. *p < .10; **p < .05; ***p < .01.

 


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  		Fig. 4. Bivariate distribution of {Delta} pre- and posttreatment HSV-2 IgG antibody titer levels and mean postrelaxation stress levels.

 




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