Psychosomatic Medicine
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Williams, R. B.
Right arrow Articles by Siegler, I. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Williams, R. B.
Right arrow Articles by Siegler, I. C.
Related Collections
Right arrow Other Cardiovascular Medicine
Right arrow Neuroendocrine
Right arrow Stress and Coping

Central Nervous System Serotonin Function and Cardiovascular Responses to Stress

Redford B. Williams, MD, Douglas A. Marchuk, PhD, Kishore M. Gadde, MD, John C. Barefoot, PhD, Katherine Grichnik, MD, Michael J. Helms, BS, Cynthia M. Kuhn, PhD, James G. Lewis, PhD, Saul M. Schanberg, MD, PhD, Mark Stafford-Smith, MD, Edward C. Suarez, PhD, Greg L. Clary, MD, Ingrid K. Svenson, BSc and Ilene C. Siegler, PhD

From the Departments of Psychiatry and Behavioral Sciences (R.B.W., J.C.B., G.L.C., K.M.G., M.J.H., I.C.S., E.C.S.), Anesthesiology (K.G., M.S.-S.), Pharmacology and Cancer Biology (C.M.K., S.M.S.), Pathology (J.G.L.), and Genetics (D.A.M., I.K.S.), Duke University Medical Center, Durham, North Carolina.



View larger version (33K):

[in a new window]
  		Fig. 1. CSF 5HIAA levels (mean ± SEM) in subjects with l/l, l/s, and s/s 5HTTLPR genotypes. Subjects with l/l and l/s do not differ, and level of l/l and l/s subjects combined is higher than that of s/s subjects. p = .006, one-way ANOVA.

 


View larger version (25K):

[in a new window]
  		Fig. 2. A, MAP (mean ± SEM) during rest and stress periods. Subjects with high (Hi, based on median split) levels of 5HIAA show a larger increase in MAP than subjects with low (Lo) 5HIAA levels (two-way ANOVA, group-by-period interaction: p < .001). B, Subjects with l/l or l/s genotype show larger MAP increases than s/s subjects (two-way ANOVA, group-by-period interaction: p < .0001).

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Psychosomatic Society