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Relationship Among Plasma Cortisol, Catecholamines, Neuropeptide Y, and Human Performance During Exposure to Uncontrollable Stress

Charles A. Morgan, III, MD, MA, Sheila Wang, PhD, Ann Rasmusson, MD, Gary Hazlett, PsyD, George Anderson, MD and Dennis S. Charney, MD

From Yale University School of Medicine (C.A.M., S.W., A.R., G.A., D.S.C.), New Haven, Connecticut; National Center for PTSD, VA New England Healthcare Systems (C.A.M., S.W., A.R., D.S.C.), West Haven, Connecticut; and Psychological Applications Directorate (G.H.), Fort Bragg, North Carolina.



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Fig. 1. (A) NE at baseline ({blacksquare}) and during stress ({blacktriangleup}). Acute stress significantly increased NE in all subjects. NE release was significantly greater in SF soldiers (p < .05). (B) EPI at baseline ({blacksquare}) and during stress ({blacktriangleup}). Exposure to stress significantly increased EPI (p < .0001). No significant group differences were observed.

 


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Fig. 2. NPY and NE during stress. Correlation between change in NPY and change in NE (r = 0.53, p < .02). {blacksquare} = general troops; {blacktriangleup} = Special Forces. Total population R2 = 0.2830 ({blacksquare} = 0.00; {blacktriangleup} = 1.00).

 


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Fig. 3. Cortisol and NPY during stress. Correlation between change in NPY and change in cortisol (r = 0.73, p < .001). {blacksquare} = general troops; {blacktriangleup} = Special Forces. Total population R2 = 0.5387 ({blacksquare} = 0.00; {blacktriangleup} = 1.00).

 


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Fig. 4. Cortisol and dissociation during stress. R2 = 0.2379.

 


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Fig. 5. Cortisol and performance during stress. R2 = 0.3346.

 





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