Psychosomatic Medicine
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Magnetic Resonance Spectroscopic and Relaxometric Determination of Bone Marrow Changes in Anorexia Nervosa

Franziska Geiser, MD, Dipl-Psych, Petra Mürtz, PhD, Dipl-Phys, Götz Lutterbey, MD, Frank Träber, PhD, Dipl-Phys, Wolfgang Block, Dipl-Biol, Katrin Imbierowicz, MD, Guntram Schilling, MD, Dipl-Psych, Hans Schild, MD and Reinhard Liedtke, MD

From the Psychosomatic Clinic (F.G., K.I., G.S., R.L.) and the Clinic for Radiology (P.M., G.L., F.T., W.B., H.S.), University of Bonn, Bonn, Germany.



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Fig. 1. T2 measurement by SE series of localized 1H spectra in a 29-year-old patient with AN. a) Display of a 10 x 10 x 30-mm voxel of interest in the left femur diaphysis on T2-weighted TSE (2500/120 ms) image before treatment. b) Stacked plot of 1H spectra with increasing echo delays (TE), obtained before treatment (BMI = 13.9 kg/m2). c) Stacked plot of 1H spectra after 3 months of psychosomatic treatment (BMI = 15.4 kg/m2).

 


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Fig. 2. Box plots (median, 25th to 75th percentiles, and range) of MR marrow measurements in the AN and control groups.

 


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Fig. 3. BMI and T1 relaxation time in the femur epiphysis in AN patients (r = -0.49, R2 (regression analysis) = 0.24).

 





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