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Slow Recovery From Voluntary Hyperventilation in Panic Disorder

Frank H. Wilhelm, PhD, Alexander L. Gerlach, Dr rer nat and Walton T. Roth, MD

From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford and the Department of Veterans Affairs Health Care System, Palo Alto, California. Dr. Gerlach is currently at the Westfälische Wilhelms-Universität Münster, Germany.



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Fig. 1. Means and standard errors of self-reported anxiety and minute-by-minute mean end-tidal pCO2 for the three groups over the course of the experiment. BASE is the baseline. 6 x FB/REC refers to the six 1-minute fast-breathing periods and 1-minute recovery periods, the following FB refers to the 3-minute fast-breathing period, and REC refers to the 10-minute final recovery period. Anxiety ratings were not evaluated during the initial six recovery periods. a marks the first time point where the panic disorder patients differ from the other groups (ANCOVA with last 2 minutes of FB as covariate: F(2,53) = 4.01, p < .02).

 


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Fig. 2. Means and standard errors of selected physiological measures for the three groups at the baseline (BASE), the 3-minute fast-breathing period (FB), and the final recovery period (REC).

 





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