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Elevated Stress Hormone Levels Relate to Epstein-Barr Virus Reactivation in Astronauts

From the Department of Pathology (R.P.S., A.D.T.B.), University of Texas Medical Branch, Galveston, TX; and Life Sciences Research Laboratories (D.L.P.), National Aeronautics and Space Administration, Lyndon B. Johnson Space Center, Houston, TX.

View larger version (20K): [in a new window]   Fig. 1. Change in anti-VCA, anti-EBNA, and anti-measles virus IgG antibody titers before (AME and L-10) and after (R+0 and R+3) spaceflight. AME = annual medical exam (baseline). *p < .05; **p < .01.

View larger version (28K): [in a new window]   Fig. 2. Changes in plasma cortisol (PCort; µg/dl) and urinary cortisol (UCort), epinephrine (UEpi), and norepinephrine (UNor; all µg/24 h) at landing (R+0) as compared with preflight (L-10) levels. *p < .05.

View larger version (29K): [in a new window]   Fig. 3. Postflight changes in stress hormones in astronauts with or without evidence of EBV reactivation after spaceflight. Cortisol = urinary cortisol; EPI = urinary epinephrine; NE = urinary norepinephrine. *p < .05; **p < .025.