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Sex Differences in Glucocorticoid Sensitivity of Proinflammatory Cytokine Production After Psychosocial Stress

From the Center for Psychobiological and Psychosomatic Research (N.C.S., D.H.H., R.E., C.K.), University of Trier, Trier, Germany; and Institute of Physiological Psychology II (N.R., C.K.), University of Düsseldorf, Düsseldorf, Germany.

View larger version (23K): [in a new window]   Fig. 1. Salivary free cortisol levels before and after psychosocial stress (TSST) in men and women. Values are means ± SEM.

View larger version (20K): [in a new window]   Fig. 2. Absolute numbers of monocytes before and after psychosocial stress (TSST) in men and women.

View larger version (18K): [in a new window]   Fig. 3. A, DEX inhibition of LPS-stimulated production of TNF- before and after TSST in men and women. B, Glucocorticoid sensitivity of LPS-stimulated TNF- production before and after psychosocial stress (TSST) in men and women. The IC50 indicates the concentration of DEX required for 50% inhibition of cytokine production.

View larger version (18K): [in a new window]   Fig. 4. A, DEX inhibition of LPS-stimulated production of IL-6 before and after TSST in men and women. B, Glucocorticoid sensitivity of LPS-stimulated IL-6 production before and after psychosocial stress (TSST) in men and women.