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Physiologic Markers of Chronic Stress in Premenopausal, Middle-Aged Women

Lynda H. Powell, PhD, William R. Lovallo, PhD, Karen A. Matthews, PhD, Peter Meyer, PhD, A. Rees Midgley, MD, Andrew Baum, PhD, Arthur A. Stone, PhD, Lynn Underwood, PhD, Judith J. McCann, DNSc, RN, Kristi Janikula Herro, MFA and Marcia G. Ory, PhD, MPH

From the Department of Preventive Medicine (L.H.P., P.M.) and the Institute For Healthy Aging (J.J.M., K.J.H.), Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois; the VA Medical Center and Department of Psychiatry and Behavioral Sciences (W.R.L.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; the Department of Psychiatry (K.A.M.) and Psychology (A.B.), University of Pittsburgh, Pittsburgh, Pennsylvania; the Reproductive Sciences Program (A.R.M.), University of Michigan, Ann Arbor, Michigan; the Department of Psychiatry (A.A.S.), State University of New York at Stony Brook; The Fetzer Institute (L.U.), Kalamazoo, Michigan; and Behavioral and Social Science Research Program (M.G.O.), National Institute on Aging, National Institutes of Health, Bethesda, Maryland.



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  		Fig. 1. Salivary cortisol over 2 days and in response to a 0.5-mg dexamethasone suppression test in stressed and nonstressed women. w = Wake-up time; w + 20 = 20 minutes after wake-up; 12 = noon; 2 = 2 PM; 4 = 4 PM; 6 = 6 PM; 9 = 9 PM; b = bedtime. Data were transformed with the natural logarithm.

 


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  		Fig. 2. Urinary testosterone over 2 days in stressed and nonstressed women.

 




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