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Fatigue and Proinflammatory Cytokine Activity in Breast Cancer Survivors

From the Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center (J.E.B., P.A.G.), the Schools of Medicine and Public Health (P.A.G.), the Center for Interdisciplinary Research in Immunology and Disease (N.A.), and the Department of Microbiology and Immunology (J.L.F.), the University of California, Los Angeles, California.

View larger version (24K): [in a new window]   Fig. 1. Levels of serum immune markers for fatigued and nonfatigued breast cancer survivors. Fatigued survivors showed significantly higher levels of interleukin 1 receptor antagonist (IL-1ra), soluble tumor necrosis factor receptor II (sTNF-RII), and neopterin than nonfatigued survivors, controlling for relevant health behaviors (all p values < .05). The lower boundary of each box represents the 25th percentile, and the upper boundary represents the 75th percentile. The line inside each box represents the median. Lines outside each box extend to the largest and smallest observed values within 1.5 box lengths.