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Diurnal Variations in Coagulation and Fibrinolysis in Vital Exhaustion

From the Departments of Psychiatry and Neuropsychology (R.v.D.), Hematology (K.H., C.v.Z.), Medical, Clinical, and Experimental Psychology (A.A.), Maastricht University, Maastricht, The Netherlands; and the Department of Medical and Clinical Psychology (W.J.K.), Uniformed Services University of the Health Sciences, Bethesda, MD.

View larger version (17K): [in a new window]   Fig. 1. Diurnal variations in measures of coagulation and fibrinolysis in exhausted individuals () and controls (). Data represent mean ± SEM. The coagulation measures F1+2, TAT, and VII:a and all fibrinolytic measures displayed significant diurnal variations (all p values < .01). Exhausted individuals, however, had significantly higher levels of tPA:ag, PAI-1:act, and tPA-PAI:ag at 7:00 AM (all p values < .04), whereas these levels were similar to those of controls at 6:00 PM (all p values > .10). This indicates a more pronounced diurnal variation in VE with respect to fibrinolytic measures. A similar, more pronounced diurnal variation in VE with respect to coagulation measures was absent (all p values > .10). Significantly higher levels of F1+2 and FNG were found in VE both at 7:00 AM and at 6:00 PM (p = .02), and a similar trend was found for VII:c (p = .07). No significant group differences were found in TAT, VII:a, VIII:c, and vWf:ag (all p values > .10).