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Stressful Life Events Precede Exacerbations of Multiple Sclerosis

Kurt D. Ackerman, MD, PhD, Rock Heyman, MD, Bruce S. Rabin, MD, PhD, Barbara P. Anderson, PhD, Patricia R. Houck, MSH, Ellen Frank, PhD and Andrew Baum, PhD

From the Departments of Psychiatry (K.D.A., B.P.A., P.R.H., E.F., A.B.), Neurology (R.H.), Pathology (B.S.R.), and Psychology (A.B.), University of Pittsburgh, Pittsburgh, Pennsylvania.



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  		Fig. 1. Time from most recent stressor to the onset of a randomly selected exacerbation and control period (42-day maximum) in women with relapsing-remitting or secondary-progressive MS. Data are expressed as mean ± SEM. ***p < .001.

 


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  		Fig. 2. Scatter plot of the interval between exacerbations and the rate of life events during that interval for women with relapsing-remitting or secondary-progressive MS.

 




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