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Herpes Viruses, Cytokines, and Altered Hemostasis in Vital Exhaustion

From the Departments of Medical Microbiology (A.v.d.V., C.B.), Psychiatry and Neuropsychology (R.v.D., M.M.), Hematology (K.H.), and Medical, Clinical, and Experimental Psychology (A.A.), Maastricht University, Maastricht, The Netherlands.

View larger version (13K): [in a new window]   Fig. 1. Interaction of vital exhaustion with pathogen burden on selected measures of hemostasis and inflammation. Group 1 comprised individuals with low stress and low PB (N = 25); group 2 comprised individuals with low stress and high PB or high stress and low PB (intermediate group; N = 13); and group 3 comprised individuals with high stress and high PB (N = 21). Significant linear increases were found in fibrinogen, all fibrinolytic measures (PAI-1:act is shown), and in IL-1ra, IL-6 (data are shown), and IL-10 (all p values < .01). Higher-order trends were not significant (all p values > .10). Data are mean + standard error of mean. The indicated significance levels are those of Bonferroni post hoc multiple comparisons.