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Acute Psychological Stress: Effects on Chemotaxis and Cellular Adhesion Molecule Expression

From Department of Psychiatry (L.R., S.S., P.M.), University of California, San Diego; and Cousins Center for Psychoneuroimmunonology (M.I.), Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California.

View larger version (11K): [in a new window]   Fig. 1. Chemotaxis of peripheral blood mononuclear cells from African-American subjects reading magazines (o) or undergoing a speech task (127). Data are presented as cells migrating to FMLP-divided random migration of cells to media ± SEM. Blood was drawn at baseline (BL), immediately after the speech/reading task (0), and 20 minutes after the task (20). The two groups showed a differential change across the session with a significant group x time interaction (F[2,54] = 3.7, p = .03).

View larger version (10K): [in a new window]   Fig. 2. Chemotaxis of peripheral blood mononuclear cells from African-American subjects reading magazines (o) or undergoing a speech task (127). Data are presented as cells migrating to SDF-1 divided random migration of cells to media ± SE. Blood was drawn at BL, immediately after the speech/reading task (0), and 20 minutes after the task (20). The two groups showed a differential change across the session with a significant group x time interaction (F[2,54] = 3.2, p < .05).

View larger version (9K): [in a new window]   Fig. 3. Percentage of Mac-1 positive lymphocytes from African-American subjects reading magazines (o) or undergoing a speech task (127). Data are presented as mean ± SE. Blood was drawn at BL, immediately after the speech/reading task (0), and 20 minutes after the task (20). The two groups showed a differential change across the session with a significant group x time interaction (F(2,54) = 3.2, p < .05).

View larger version (10K): [in a new window]   Fig. 4. Percentage of L-selectin positive lymphocytes from African-American subjects reading magazines (o) or undergoing a speech task (127). Data are presented as means ± SE. Blood was drawn at BL, immediately after the speech/reading task (0), and 20 minutes after the task (20). The two groups showed a differential change across the session with a significant group x time interaction (F(2,54) = 6.1, p = .004).

View larger version (10K): [in a new window]   Fig. 5. Plasma levels of soluble L-selectin from African-American subjects reading magazines (o) or undergoing a speech task (). Data are presented as mean (ng/ml) ± SE. Blood was drawn at BL, immediately after the speech/reading task (0), and 20 minutes after the task (20). The two groups showed a differential change across the session with a significant group x time interaction (F(2,54) = 3.1, p = .05).

View larger version (13K): [in a new window]   Fig. 6. A significant positive correlation between lymphocyte Mac-1 expression and E levels immediately after the task was revealed after covarying for basal Mac-1 and E levels (r = .43, p = .05).

View larger version (13K): [in a new window]   Fig. 7. A significant negative correlation between lymphocyte L-selectin expression and E levels immediately after the task was found after covarying for basal L-selectin and E levels (r = -0.46, p = .04).