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Allelic Variation in the Serotonin Transporter Gene-Linked Polymorphic Region (5-HTTLPR) and Cardiovascular Reactivity in Young Adult Male and Female Twins of European-American Descent

From the Centers for Behavioral and Preventive Medicine, Brown Medical School and The Miriam Hospital (J.M.McC.), Providence, RI; Department of Psychology, University of Pittsburgh (M.B., M.F.P.-G., S.B.M.), Pittsburgh, PA; Department of Psychiatry, University of Pittsburgh Medical Center (M.F.P.-G., S.B.M.) Pittsburgh, PA; and Department of Human Genetics and Graduate School of Public Health, University of Pittsburgh (R.E.F.), Pittsburgh, PA.

View larger version (45K): [in a new window]   Fig. 1. Mean (± standard error) heart rate reactivity across task by genotype at 5-HTTLPR among men and women. (A) Full sample (N = 382). (B) Genetically independent sample 1 (N = 191). (C) Genetically independent sample 2 (N = 191).

View larger version (39K): [in a new window]   Fig. 2. Mean (± standard error) squared sibling differences in HR reactivity across task by degree of allele sharing at 5-HTTLPR (N = 60 sib-pairs).