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Blunted Cortisol Responses to Psychosocial Stress in Asthmatic Children: A General Feature of Atopic Disease?

From the Department of Psychobiology, University of Trier (A.B.-K., D.H.), Trier, Germany; Department of Child Psychiatry, Mutterhaus der Borromäerinnen (K. von-A.), Trier, Germany; and Department of Pediatrics, Mutterhaus der Borromäerinnen (S.K., S.W., W.R.), Trier, Germany.

View larger version (21K): [in a new window]   Fig. 1. Cortisol responses to psychosocial stress ("Trier Social Stress-Test"; TSST) in children with allergic asthma (AA) and nonatopic control children. Figure insert: cortisol response (area under the curve, AUC) to the TSST in AA children and nonatopic controls. *p < .05.

View larger version (32K): [in a new window]   Fig. 2. Heart rate responses to psychosocial stress ("Trier Social Stress-Test"; TSST) in children with allergic asthma (AA) and nonatopic control children.

View larger version (13K): [in a new window]   Fig. 3. Morning cortisol levels after waking up and 10, 20, and 30 minutes after awakening one day before the TSST (A) and one day (B) and two days (C) after the TSST.