Psychosomatic Medicine
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Joachim, R. A.
Right arrow Articles by Klapp, B. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Joachim, R. A.
Right arrow Articles by Klapp, B. F.
Related Collections
Right arrow Animal Studies
Right arrow Pulmonary
Right arrow Stress and Coping

Stress Enhances Airway Reactivity and Airway Inflammation in an Animal Model of Allergic Bronchial Asthma

Ricarda A. Joachim, MD, David Quarcoo, MD, Petra C. Arck, MD, Udo Herz, PhD, Harald Renz, MD and Burghard F. Klapp, MD

From the Department of Internal Medicine, Charité-Campus Virchow, Humboldt University (R.A.J., P.C.A., B.F.K.), Berlin; Department of Pediatrics, Charité-Campus Virchow, Humboldt University (D.Q.), Berlin; and Department of Clinical Chemistry and Molecular Diagnostic, Philipps-Universität (U.H., H.R.), Marburg, Germany.



View larger version (14K):

[in a new window]
  		Fig. 1. Experimental protocol. After systemic sensitization on days 0, 14, and 21, OVA IP mice were challenged twice with OVA aerosol on days 26 and 27. Coinciding with the first challenge, the stress group was exposed to sound stress for 24 hours while controls remained undisturbed.

 


View larger version (24K):

[in a new window]
  		Fig. 2. Effect of stress on AHR measured in OVA-sensitized and airway-challenged CBA/J mice. Indicated are mean and SEM from stressed (N = 8) and nonstressed (N = 8) sensitized CBA/J mice. The frequency that caused 50% of maximal contraction (ES50) was calculated. Airway contractility is expressed as percent of nonstressed control (2.1 Hz). * p < .05.

 


View larger version (23K):

[in a new window]
  		Fig. 3. Total leukocyte number and cell differentiation in BAL fluid of OVA-sensitized and airway-challenged CBA/J mice. Indicated are mean and SD from stressed (N = 12) and nonstressed (N = 9) sensitized animals (Leukos = leukocytes, Lymphos = lymphocytes, Eos = eosinophil granulocytes, Neutros = neutrophil granulocytes, Mono/Mac=Monocytes/Macrophages). * p < .05.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the American Psychosomatic Society