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Sleep Enhances the Human Antibody Response to Hepatitis A Vaccination

Tanja Lange, MD, Boris Perras, MD, Horst L. Fehm, MD and Jan Born, PhD

From the Department of Neuroendocrinology (T.L., J.B.) and Department of Internal Medicine (B.P.; H.L.F.), University of Lübeck, Lübeck, Germany.



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  		Fig. 1. HAV antibody titers. Mean (± SEM) anti-HAV titer in mIU/ml before (day 0) and after (days 5–14 and day 28) hepatitis A vaccination in subjects who had either regular sleep on the night after vaccination (thin line, open circles) or were kept awake on this night (thick line, filled circles). *p = .018, for comparison between the effects of sleep and the wakefulness on day 28.

 




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