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Temporal Relations Between Unexplained Fatigue and Depression: Longitudinal Data From an International Study in Primary Care

Petros Skapinakis, MD, MPH, PhD, Glyn Lewis, FRCPsych, PhD and Venetsanos Mavreas, MD, PhD

From the Department of Psychiatry (P.S., V.M.), University of Ioannina, School of Medicine, Greece; and the Department of Psychiatry (P.S., G.L.), University of Bristol, UK.



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  		Figure 1. A vicious cycle model of depression and fatigue. In addition to common and distinct risk factors, unexplained fatigue and depression might also cause each other

 




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