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Historical Sexual Abuse and Current Thyroid Axis Profiles in Women With Premenstrual Dysphoric Disorder

Susan S. Girdler, PhD, Kate S. Thompson, BS, Kathleen C. Light, PhD, Jane Leserman, PhD, Cort A. Pedersen, MD and Arthur J. Prange, Jr., MD

From the Departments of Psychiatry (S.S.G., K.C.L., J.L., C.A.P., A.J.P.) and Psychology (S.S.G., K.S.T., K.C.L.), University of North Carolina at Chapel Hill, Chapel Hill, NC.



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  		Figure 1. Mean (+ SEM) serum concentrations of total T3 in women with PMDD with previous SA (PMDD-Sexual Abuse), in women with PMDD with no previous SA (PMDD-No Sexual Abuse), and in women without PMDD, in both the follicular and luteal phases of the menstrual cycle (main effect of group: p = .02).

 


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  		Figure 2. Ratio of free T3 to free T4 in women with PMDD with previous SA (PMDD-Sexual Abuse), in women with PMDD with no previous SA (PMDD-No Sexual Abuse), and in women without PMDD, in both the follicular and luteal phases of the menstrual cycle (phase by group: p = .05).

 


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  		Figure 3. Ratio of serum total T3 to free T4 in women with PMDD with previous SA (PMDD-Sexual Abuse), in women with PMDD with no previous SA (PMDD-No Sexual Abuse), and in women without PMDD, in both the follicular and luteal phases of the menstrual cycle (main effect of group: p = .005).

 




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