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The Effect of Life Stress on Symptoms of Heartburn

From the Center for Neurovisceral Sciences & Women’s Health, Departments of Medicine (M.M., L.C., L.Z.F., R.B., E.A.M.), Physiology (E.A.M.), Psychiatry & Biobehavioral Sciences (B.D.N., E.A.M.), UCLA, Los Angeles, CA; Greater Los Angeles Healthcare System, VA Medical Center (B.D.N.), Los Angeles, CA; and University of Arizona/VA Medical Center GI Division (R.F.), Tucson, AZ.

View larger version (23K): [in a new window]   Figure 1. Impact of major life stress in previous 6 months on diary ratings. Subjects with presence of HIS during the past 6 months by team rating show increased heartburn symptom severity, impact, daily stress, and other pains on daily diary. Error bars represent SD. * p < .05 level (2-tailed). **p < .01 level (2-tailed).

View larger version (14K): [in a new window]   Figure 2. Symptom severity during 6 months for subjects with a major life stressor versus no major life stressor in past 6 months. Subjects with the presence of high-impact stressors by team rating show greater heartburn severity at 0, 2, and 4 months. Error bars represent SD. * p < .05 level (2-tailed).