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Elevated Plasma C-Reactive Protein in Chronically Distressed Subjects Who Carry the A Allele of the TNF- -308 G/A Polymorphism

From the Institute for Behavioral Sciences, Swiss Federal Institute of Technology, Zürich, Switzerland (P.J., R.v.K., J.E.F.); Department of General Internal Medicine, University Hospital, Bern, Switzerland (R.v.K.) and the Institute of Clinical Chemistry, University Hospital Zürich, Switzerland (F.E.M.).

View larger version (13K): [in a new window]   Figure 1. Interaction between genotype and exhaustion related to plasma levels of C-reactive protein (CRP). Although there was no association between CRP and exhaustion for carriers of the GG wild-type, subjects with the GA or AA variant showed a dose–response relationship between levels of exhaustion and plasma levels of CRP. Among the GA/AA individuals, there were 22 subjects with no exhaustion, 31 subjects with moderate exhaustion, and 20 subjects with severe exhaustion. Data show means ± SEM of anti-log transformed CRP values derived from multivariable adjusted analysis on log-transformed CRP values. Error bars indicate estimated standard error of the mean.