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Attenuation of Laboratory-Induced Stress in Humans After Acute Administration of Melissa officinalis (Lemon Balm)

From the Human Cognitive Neuroscience Unit, Division of Psychology, University of Northumbria, Newcastle upon Tyne, NE1 8ST UK.

View larger version (57K): [in a new window]   Figure 1. The on-screen layout of the Defined Intensity Stressor Simulation battery. The concurrent tasks comprise (clockwise from top left) "mathematical processing," "auditory monitoring," "memory search," and "visual monitoring." The participant’s aggregate score for the four tasks is shown at the center of the display. All responses are made via a standard computer mouse.

View larger version (31K): [in a new window]   Figure 2. Schematic representation of the running order of the experiment, with mean scores (with standard errors) for each of the mood assessments, and "change from baseline" data (change in mood score during predose Defined Intensity Stressor Simulation (DISS) minus change in mood scores during 1 hour posttreatment DISS).

View larger version (16K): [in a new window]   Figure 3. Effects of treatment (300 mg, 600 mg Melissa officinalis) on modulation of mood during the Defined Intensity Stressor Simulation battery (*p < .05; **p < .001 from planned comparisons).

View larger version (28K): [in a new window]   Figure 4. Effects of treatment (300 mg, 600 mg Melissa officinalis) on performance accuracy of the four concurrent tasks making up the Defined Intensity Stressor Simulation battery. Scores are change in number of correct answers for "math correct" and percentage change for the other three tasks (*p < .05 from planned comparisons).