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Differential Immune Cell Chemotaxis Responses to Acute Psychological Stress in Alzheimer Caregivers Compared to Non-caregiver Controls

Laura Redwine, PhD, Paul J. Mills, PhD, Merna Sada, BS, Joel Dimsdale, MD, Thomas Patterson, PhD and Igor Grant, MD

From the Department of Psychiatry, University of California, San Diego.



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  		Figure 1. Chemotaxis of peripheral blood mononuclear cells from Alzheimer’s caregivers to 1 nM ({circ}) and 10 nM ({square}) FMLP or noncaregivers to 1 nM (•) and 10 nM ({blacksquare}) FMLP. Data are presented as cells migrating to FMLP divided by random migration of cells to media ± SEM. Blood was drawn at baseline and following the speech tasks. There was a differential change across the session with a significant dose x group x time interaction (F (1,25) = 5.1, p = .03).

 


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  		Figure 2. Chemotaxis of peripheral blood mononuclear cells from Alzheimer’s caregivers to 25 pg/ml ({circ}) and 100 pg/ml ({square}) SDF-1 or noncaregivers to 25 pg/ml (•) and 100 pg/ml ({blacksquare}) SDF-1. Data are presented as cells migrating to SDF-1 divided by random migration of cells to media ± SEM. Blood was drawn at baseline and following the speech tasks. There was a differential change across the session with a significant group x time interaction (F (1,24) = 4.2, p = .05).

 


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  		Figure 3. Chemotaxis of peripheral blood mononuclear cells from Alzheimer’s caregivers to 1 nM ({circ}) and 100 nM ({square}) ISO or noncaregivers to 1n M (•) and 100 nM ({blacksquare}) ISO. Data are presented as cells migrating to ISO divided by random migration of cells to media ± SEM. There were no significant interactions.

 


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  		Figure 4. (A) Correlations between chemotaxis to ISO (100 nM) and epinephrine at baseline. (B) Correlations between chemotaxis to ISO (100 nM) and epinephrine immediately following the speech task.

 




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