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Is There a Functional Neural Correlate of Individual Differences in Cardiovascular Reactivity?

From the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View larger version (62K): [in a new window]   Figure 2. Displayed in red are clusters of voxels that showed a significant change in blood oxygen-level dependent (BOLD) activation from the congruent to the incongruent conditions of a Stroop stressor. These clusters of activation were revealed by random-effects region-of-interest (ROI) ANOVAs on BOLD activation within the orbitofrontal cortex, anterior cingulate, and the left and right insula. Gray shading depicts the anatomical boundary (mask) that was used to define each ROI. Results are overlaid on a canonical brain from the Montreal Neurological Institute (MNI).

View larger version (22K): [in a new window]   Figure 3. Left panel: Displayed in red is a cluster of voxels in the posterior cingulate cortex (Brodmann area 31; Talairach coordinates for peak activation voxel: X = 1, Y = –44, Z = 38) where high cardiovascular reactors showed an increase, but low reactors a decrease, in blood oxygen level dependent (BOLD) activation during the incongruent relative to the congruent condition of a Stroop stressor. Results are overlaid on a canonical brain from the Montreal Neurological Institute (MNI). Right panel: Plotted is the standardized incongruent-minus-congruent condition difference in posterior cingulate BOLD activation for both high and low cardiovascular reactors.

View larger version (28K): [in a new window]   Figure 1. Change in systolic blood pressure (SBP) from baseline to the congruent and incongruent conditions of a Stroop stressor for high and low cardiovascular reactors. High reactors showed a significant increase in SBP from a resting baseline to both congruent and incongruent conditions (p values <0.05); low reactors did not show a significant change in SBP from baseline to either condition (p values >0.27).