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Effect of Behavioral Interventions on Insulin Sensitivity and Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit

Julie A. Gonzales, PhD, Angela Szeto, MS, Armando J. Mendez, PhD, Julia Zaias, DVM, Jamespaul Paredes, PhD, Caroline V. Caperton, BS, Maria M. Llabre, PhD, Jon E. Levine, PhD, Ronald B. Goldberg, MD, Neil Schneiderman, PhD and Philip M. McCabe, PhD

From the Departments of Psychology (J.A.G., A.S., J.P., C.C., M.M.L., N.S., P.M.M), Medicine (A.M., R.B.G.), and Pathology (J.Z.), University of Miami, Coral Gables, and the University of Miami School of Medicine, Miami, FL; and the Department of Neurobiology and Physiology (J.E.L.), Northwestern University, Evanston, IL.



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  		Figure 1. Plasma glucose and insulin values from control Watanabe heritable hyperlipidemic and control New Zealand white rabbits sampled during intravenous glucose tolerance tests. (A and B) Intravenous glucose tolerance tests results at 3 months of age. (C and D) Results from the same animals at 7 months of age.

 


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  		Figure 2. Plasma glucose and insulin values from 3 groups of Watanabe heritable hyperlipidemic rabbits (exercise, diet, control) sampled during intravenous glucose tolerance tests. (A and B) Intravenous glucose tolerance test results at 3 months of age (preintervention). (C and D) Values from the same animals at 7 months of age (postintervention).

 




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