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Depression-Related Hyperglycemia in Type 1 Diabetes: A Mediational Approach

Patrick J. Lustman, PhD, Ray E. Clouse, MD, Paul S. Ciechanowski, MD, Irl B. Hirsch, MD and Kenneth E. Freedland, PhD

From the Departments of Psychiatry (P.J.L., R.E.C., K.E.F.) and Medicine (R.E.C.), Washington University School of Medicine, St. Louis, MO; the Department of Veterans Affairs Medical Center (P.J.L.), St. Louis, MO; and the Departments of Psychiatry and Behavioral Sciences (P.S.C.) and Medicine (I.B.H.), University of Washington, Seattle, WA.



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  		Figure 1. Mean glycosylated hemoglobin (HbA1c) level in relation to depression status after adjusting for weight and total daily insulin dose. HbA1c levels were significantly higher in depressed compared with nondepressed subjects and showed a stepwise increase in relation to depression severity within the depressed subject group. Error bars represent standard error of mean.

 




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