This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Klosterhalfen, S. Articles by Enck, P. Search for Related Content PubMed PubMed Citation Articles by Klosterhalfen, S. Articles by Enck, P. Related Collections Gastrointestinal Therapeutic Interventions

Latent Inhibition of Rotation Chair-Induced Nausea in Healthy Male and Female Volunteers

From the Institute of Medical Psychology, University Hospitals Düsseldorf, Düsseldorf, Germany (S. Klosterhalfen, S. Kellerman, U.S.); the Department of Psychoendocrinology, Technical University of Dresden, Dresden, Germany (J.W., C.K.); the Department of Psychology, University of York, York, United Kingdom (G.H.); and the Department of Psychosomatic Medicine and Psychotherapy, University Hospitals Tüebingen, Tüebingen, Germany (P.E.).

View larger version (18K): [in a new window]   Figure 1. Experimental design of the study on latent inhibition (LI). Subjects were investigated on 5 consecutive days. Pre-exposure was on 1 day (group 1) or on 3 days (group 3) in the rotation chair (but without rotation), or in a neutral environment on all three occasions (group 0). On days 3 and 4, all subjects were rotated in the chair; on day 5, all subjects were seated in the rotation chair but not rotated.

View larger version (33K): [in a new window]   Figure 2. Baseline symptom rating (mean ± SEM) in groups 0, 1, and 3 by gender on day 5. Independent effects of group and gender (F = 3.356; p = .082; and F = 3.478; p = .051, respectively) were observed for AN.

View larger version (35K): [in a new window]   Figure 3. Rotation-induced cortisol increases (µmol/l, mean ± SEM) by gender on days 3 and 4. Cortisol rose in all subjects on both days (main effects of rotation: F = 29.22; p < .001), but the effect also depended on days and gender (main effect of days: F = 8.02; p = .01; days x rotation: F = 7.06; p = .015; rotation x gender: F = 6.07; p = .018).

View larger version (46K): [in a new window]   Figure 4. Baseline and postrotation TNF- values (µmol/l, mean ± SEM) by gender on days 3 and 4. The rotation-induced decrease was significant (main effect of rotation: F = 4.49; p = .048), whereas apparent gender and day effects were not significant any longer when controlled for baseline differences.