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A Study of Antihypertensive Drugs and Depressive Symptoms (SADD-Sx) in Patients Treated With a Calcium Antagonist Versus an Atenolol Hypertension Treatment Strategy in the International Verapamil SR-Trandolapril Study (INVEST)

L. Douglas Ried, PhD, Michael J. Tueth, MD, Eileen Handberg, PhD, Stuart Kupfer, MD, Carl J. Pepine, MD and the INVEST Study Group

From the Rehabilitation Outcomes Research Center (L.D.R.) and the Department of Psychiatry (M.J.T.), Malcom Randall Veterans Affairs Medical Center, Department of Veterans Affairs, Gainesville, Florida; the College of Pharmacy, University of Florida, Gainesville, Florida (L.D.R.); the Department of Psychiatry (M.J.T.) and the Division of Cardiovascular Medicine, Department of Medicine (E.H., C.J.P.), College of Medicine, University of Florida, Gainesville, Florida; and Abbott Laboratories, Abbott Park, Illinois (S.K.).



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  		Figure 1. Flow diagram of patients’ progression through the SADD-Sx substudy of the International Verapamil SR-Trandolapril Study (n = 2317). SADD-Sx = Study of Antihypertensive Drugs and Depressive Symptoms.

 


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  		Figure 2. Mean difference in Center for Epidemiologic Studies–Depression scale depressive symptom scores by assignment group at baseline and 1year (n = 1192).

 


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  		Figure 3. Comparison of patients’ unadjusted risk of high depressive symptoms after 1 year (n = 1192). *Unadjusted risk of being classified as "at risk of depressive symptoms" Center for Epidemiologic Studies–Depression scale score ≥23. ACE = angiotensin-converting enzyme; BP = blood pressure; CABG = coronary artery bypass graft; RR = relative risk; SD = standard deviation; SADD-Sx = Study of Antihypertensive Drugs and Depressive Symptoms.

 




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