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24-Hour Pituitary and Adrenal Hormone Profiles in Chronic Fatigue Syndrome

From the Department of Neurological and Psychiatric Services, University of Bari, Bari, Italy (A.D.G.); the Section of Neurobiology of Mood Disorders, Division of Psychological Medicine (A.D.G., A.J.C., M.H.) and the Department of Clinical Biochemistry (W.J.), The Institute of Psychiatry and Guy’s, King’s and St Thomas’ School of Medicine, London, UK; and the National Affective Disorders Unit, Bethlem Royal and Maudsley Hospitals, London, UK (A.J.C.).

View larger version (20K): [in a new window]   Figure 1. Graph showing the mean values of corticotrophin (ACTH) in patients with chronic fatigue syndrome (n = 15) and healthy control subjects (n = 10). (A) The whole 24-hour period, with each point representing the mean of values and standard errors over a 2-hour period. (B) The values at each 15-minute sampling point during the overnight (10 pm to 10 am) period.

View larger version (19K): [in a new window]   Figure 2. Graph showing the mean values and standard errors of cortisol in patients with chronic fatigue syndrome (n = 15) and healthy control subjects (n = 10) over the whole 24-hour period, with each point representing the mean of values over a 2-hour period.