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Irritability Rather Than Depression During Interferon Treatment Is Linked to Increased Tryptophan Catabolism

Sascha Russo, MD, PhD, Ido P. Kema, PhD, Elizabeth B. Haagsma, MD, PhD, Jim C. Boon, MD, Pax H.B. Willemse, MD, PhD, Johan A. den Boer, MD, PhD, Elisabeth G.E. de Vries, MD, PhD and Jakob Korf, PhD

From the Departments of Biological Psychiatry (S.R., J.C.B., J.A.B., J.K.), Pathology and Laboratory Medicine (I.P.K.), Gastroenterology and Hepatology (E.B.H.), and Medical Oncology (P.H.B.W., E.G.E.V.), University Hospital Groningen, the Netherlands.



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  		Figure 1. Plasma tryptophan levels before and during interferon treatment. Black lines indicate the presence of increased irritability.

 


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  		Figure 2. Platelet 5-HT content before and during interferon treatment. Black lines indicate the presence of increased irritability.

 




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