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Abnormal Affective Modulation of Somatosensory Brain Processing Among Patients With Fibromyalgia

Pedro Montoya, PhD, Carolina Sitges, MS, Manuel García-Herrera, MD, PhD, Raúl Izquierdo, MD, Magdalena Truyols, MS, Nicole Blay, BS and Dolores Collado, MD

From the Department of Psychology and Research Institute of Health Sciences (IUNICS), University of the Balearic Islands, Palma, Spain (P.M., C.S., N.B.); the Medical Unit for Disability Assessment, Social Security Agency, Palma, Spain (M.G.-H., R.I., D.C.); and the Pain Clinic, General Hospital, Palma, Spain (M.T.).



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  		Figure 1. Subjective ratings of ongoing pain for patients with musculoskeletal (MSK) and fibromyalgia (FM) at the beginning of the experiment and after viewing the pleasant and the unpleasant slides.

 


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  		Figure 2. Scalp distribution of somatosensory-evoked potentials (SEPs) elicited by nonpainful tactile stimulation at the second digit of the left (deviant stimuli) or the right hand (frequent stimuli) when patients were viewing either unpleasant or pleasant slides. Waveforms correspond to the SEPs at electrodes C4 and C3 for deviant and frequent stimuli, respectively. Maps represent the scalp distribution at each peak (P50, N80, P200). Time is in milliseconds. MSK indicates musculoskeletal pain; FM = fibromyalgia.

 




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