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The Role of Immune System Parameters in the Relationship Between Depression and Coronary Artery Disease

Willem J. Kop, PhD and John S. Gottdiener, MD

From the Uniformed Services University of the Health Sciences, Bethesda, MD (W.J.K.); and the Division of Cardiology, University of Maryland Hospital, Baltimore, MD (J.S.G.).



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  		Figure 1. The relationship between central nervous system correlates of depression and immune system parameters is bidirectional, mediated by neurohormonal and parasympathetic pathways. Depressive symptoms primarily affect the transition from stable CAD to acute coronary syndromes via plaque activation and prothrombotic processes (solid line) and may adversely affect the initial response to injury at early stages of coronary atherosclerosis (dashed line).

 




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