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Increased Serum Levels of 8-Hydroxy-2'-Deoxyguanosine in Clinical Depression

From the Faculty of Health Sciences (M.J.F.), Simon Fraser University, Burnaby, British Columbia, Canada; and the Department of Psychology (G.E.M.), University of British Columbia, Vancouver, British Columbia, Canada.

View larger version (43K): [in a new window]   Figure 1. Estimated marginal means (standard error of mean) of serum levels of 8-OHdG by depression status controlling for age, gender, race/ethnicity, years of education, average number of alcoholic drinks per week, average amount of physical activity per week, and body mass index. (A) Mean level of 8-OHdG in serum of depression and nondepressed participants (F [1, 153] = 4.83, p = .029). (B) Mean Level of 8-OHdG in serum of participants with major depression, minor depression, and no depression. Univariate tests showed significant group differences in levels of 8-OHdG (F [2, 152] = 4.22, p = .016). A polynomial linear contrast was significant (contrast estimate [SE] = 0.362 [0.130], p = .006). (C) Mean level of 8-OHdG in serum of participants with recurrent depression, a single episode of depression, and no depression. Univariate tests showed was a marginal difference between the groups (F [2, 152] = 2.54, p = .08). Polynomial linear contrast analysis showed a significant linear trend for history of depression (contrast estimate [SE] = 0.287 [0.129], p = .027). (D) Mean Level of 8-OHdG in serum of participants with recurrent major depression, other depression, and no depression. Univariate test showed significant differences in levels of 8-OHdG between the groups (F [2, 152] = 3.83, p = .024). A polynomial linear contrast showed a significant linear trend (contrast estimate [SE] = 0.399 [0.144], p = .006).