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Depression, Anxiety, and Nonalcoholic Steatohepatitis

From the Division of Gastroenterology (J.E.E., R.E.C.), Department of Psychiatry (P.J.L., R.E.C.), and Division of Anatomic Pathology (H.L.W.), Washington University School of Medicine, St. Louis, Missouri.

View larger version (13K): [in a new window]   Figure 1. Rates of lifetime psychiatric diagnoses in NASH and control subjects. Rates for each studied diagnosis were greater in the NASH subjects. *p < .05; **p < .01.

View larger version (10K): [in a new window]   Figure 2. Findings from the nine depression symptoms on the Patient Health Questionnaire (PHQ-9). NASH subjects endorsed more symptoms and had higher cumulative scores than the control subjects. *p < .05; **p < .01. Error bars represent SE.

View larger version (14K): [in a new window]   Figure 3. Severity of liver histology in NASH subjects in relation to presence or absence of psychiatric illness. Histological scores in each category were adjusted for subject age as described in the Methods. MDD = major depressive disorder; GAD = generalized anxiety disorder. *p < .05 compared with subjects having no psychiatric diagnosis. Error bars represent SE.